Reversing Glioblastoma-Induced Changes in Blood Marrow Hematopoiesis
We have found that CXCR3 signaling potently inhibits murine neutrophil plasticity and CXCR3 blockade slows glioma-induced neutrophil expansion, slowing tumor growth and prolonging survival.
Retrovirus-Mediated Immunotherapy in Glioblastoma
We are harnessing the ability of retroviruses to deliver effective immunotherapy directly to the tumor microenvironment, potentiating anti-tumoral effects of the immune system.
Cancer-Associated Fibroblasts in Glioblastoma
We have used single cell RNA-seq and spatial transcriptomics to identify cancer-associated fibroblasts in the perivascular niche of glioblastoma. We also defined a role for GBM stem cells in attracting these cells, and numerous pro-tumoral functions of these fibroblasts.
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Recruitment and Differentiation of Hybrid Neutrophils in Glioblastoma
We have defined pro-tumoral functions of dentritic-like "hybrid" neutrophils from skull bone marrow in glioblastoma, which we are working to inhibit in preclinical models.
Druggable Phosphomodulators of Cortactin in Glioblastoma Invasion
We have partnered with the Kumar Lab in the UC Berkeley Bioengineering department to conduct a multi-omic screen and validation of druggable candidates that regulate cortactin and drive actin remodeling in invasive glioblastoma cells
Focused Ultrasound
We are using focused ultrasound (FUS) to temporarily disrupt the blood-brain barrier to allow for more efficient delivery of chemotherapeutic agents.
c-Met/beta1 integrin Complex in Glioblastoma and Metastases
We have identified a structural complex between c-Met and beta1 integrin that drives invasive resistance in glioblastoma and metastatic spread of cancer. Current work seeks to identify small molecule inhibitors blocking the formation of this complex.
3D-Bioengineered Models to Study Glioblastoma Invasion
We have partnered with the Kumar lab in the UC Berkeley bioengineering department to use 3D tissue models for screening of druggable mediators of invasion and invasive resistance in glioblastoma.
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