The Fruits of Our Labor
Recently, the Aghi Laboratory has published research in several academic journals including Cancer Cell, Journal of Clinical Investigation, Cancer Research, and Nature Communications. See below for a selection of our recent publications.
Click here for a list of Dr. Aghi's authorships on PubMed
Preprints
Developmental plasticity and stromal co-option shape a pituitary neuroendocrine tumor transcriptional continuum
Osorio RC, Oh JY, Jung J, Ehrenberg AJ, Saha A, Lad M, Khela H, Brennick N, Giannikopoulos P, Seeley WW, Grinberg LT, Diaz A, Aghi MK.
bioRxiv [preprint]. 2025 Jun 24: 2025.06.18.659743. doi: 10.1101/2025.06.18.659743. PMID: 40666832.
In Press
Druggable genome CRISPRi screen in 3D hydrogels reveals regulators of cortactin-driven actin remodeling in invading glioblastoma cells
Hu M, Weldy A, Lovalvo I, Akins E, Jain S, Chang A, Sati A, Lad M, Lui A, Rajidi A, Kothekar A, Ding E, Kumar S, Aghi MK.
Accepted to JCI Insight, June 2026
Non-lytic viral immunotherapy induces long-term glioblastoma survival and tumor-specific immunity without eliciting an antiviral response
Haddad AF, Saha A, Collins SA, Lovalvo IM, Gill S, Montoya ML, Shukla P, Hong J, Wang E, Chuntova P, Lad M, Osorio R, Chen JS, Sathavipat M, Jain S, Chalif E, Kasahara N, Aghi MK.
Nature Communications. 2026 May 19. doi: 10.1038/s41467-026-72746-5. PMID: 42156731
Glioblastoma induces the recruitment and differentiation of dendritic-like "hybrid neutrophils" from skull bone marrow
Lad M, Beniwal A, Jain S, Shukla P, Jung J, Shah S, Yagnik G, Babikir H, Nguyen AT, Gill S, Young JS, Lui A, Salha D, Diaz A, Aghi MK.
Cancer Cell. 2024 Sep 9; 42(9). doi: 10.1016/j.ccell.2024.08.008. PMID: 39255776.
Multiomic screening of invasive GBM cells reveals targetable transsulfuration pathway alterations
Garcia JH, Akins EA, Jain S, Wolf KJ, Zhang J, Choudhary N, Lad M, Shukla P, Rios J, Seo K, Gill SA, Carson WH, Carrete LR, Zheng AC, Raleigh DR, Kumar S, Aghi MK.
J Clin Invest. 2023 Nov 16; 134(3):e170397. doi: 10.1172/JCI170397. PMID: 37971886
Single-cell RNA sequencing and spatial transcriptomics reveal cancer-associated fibroblasts in glioblastoma with protumoral effects
Jain S, Rick JW, Joshi RS, Beniwal A, Spatz J, Gill S, Chang A, Choudhary N, Nguyen AT, Sudhir S, Chalif E, Chen JS, Chandra A, Haddad AF, Wadhwa H, Shah SS, Choi S, Hayes J, Wang L, Yagnik G, Costello JF, Diaz A, Heiland DH, Aghi MK.
J Clin Invest. 2023 Mar 1;133(5):e147087. doi: 10.1172/JCI147087. PMID: 36856115
CD97 is associated with mitogenic pathway activation, metabolic reprogramming, and immune microenvironment changes in glioblastoma
Safaee MM, Wang EJ, Jain S, Chen J-S, Gill S, Garcia JH, Beniwal AS, Nguyen AT, Maclean JM, Wycoff K, Aghi MK.
Scientific Reports. 2022 Jan 27;12(1):1464. doi: 10.1038/s41598-022-05259-y. PMID: 35087132
Role of c-Met/ß1 integrin complex in the metastatic cascade in breast cancer
Lau D, Wadhwa H, Sudhir S, Jain S, Chandra A, Nguyen A, Spatz J, Shah SS, Cheng J, Safaee M, Yagnik G, Jahangiri A, Aghi MK.
JCI Insight. 2021 Jun 22;6(12):e138928. doi: 10.1172/jci.insight.138928. PMID: 34003803
Higher cytolytic score correlates with an immunosuppressive tumor microenvironment and reduced survival in glioblastoma
Haddad AF, Chen JS, Oh T, Pereira MP, Joshi RS, Aghi MK.
Scientific Reports. 2020 Oct 16;10(1):17580. doi: 10.1038/s41598-020-73793-8. PMID: 33067480
Clonal ZEB1-driven mesenchymal transition promotes targetable oncologic antiangiogenic therapy resistance
Chandra A, Jahangiri A, Chen W, Nguyen AT, Yagnik G, Pereira MP, Jain S, Garcia JH, Shah SS, Wadhwa H, Joshi RS, Weiss J, Wolf KJ, Lin J-M G, Mueller S, Rick JW, Diaz AA, Gilbert LA, Kumar S, Aghi MK.
Cancer Research. 2020 Apr 1;80(7):1498-1511. doi: 10.1158/0008-5472.CAN-19-1305. PMID: 32041837
Stratifying nonfunctional pituitary adenomas into two groups distinguished by macrophage subtypes
Yagnik G, Rutkowski M, Shah S, Aghi MK.
Oncotarget. 2019 Mar 15;10(22):2212-2223. doi: 10.18632/oncotarget.26775. PMID: 31040912
Cross-activating c-Met/β1 integrin complex drives metastasis and invasive resistance in cancer
Jahangiri A, Sidorov M, Han SW, Mascharak S, De Lay M, Wagner JR, Castro BA, Imber BS, Lu K, Bergers G, Weiss WA, Aghi MK.
Proceedings of the National Academy of Sciences. 2017 Sept 1; 114(41) E8685-E8694. doi: 10:1073/pnas.1701821114. PMID: 28973887
Role of a p53 polymorphism in the development of nonfunctional pituitary adenomas
Yagnik G, Jahangiri A, Chen R, Wagner JR, Aghi MK.
Molecular and Cellular Endocrinology. 2017 May 5; 446:81-90. doi: 10.1016/j.mce.2017.02.017. PMID: 28214592
GLUT3 upregulation promotes metabolic reprogramming associated with antiangiogenic therapy resistance
Kuang R, Jahangiri A, Mascharak S, Nguyen A, Chandra A, Flanigan PM, Yagnik G, Wagner JR, De Lay M, Carrera D, Castro BA, Hayes J, Sidorov M, Garcia J, Eriksson P, Ronen S, Phillips J, Molinaro A, Koliwad S, Aghi MK.
JCI Insight. 2017 Jan 26; 2(2): e88815. doi:10.1172/jci.insight.88815. PMID: 28138554.
Macrophage migration inhibitory factor downregulation: a novel mechanism of resistance to anti-angiogenic therapy
Castro BA, Flanigan P, Jahangiri A, Kuang R, De Lay M, Chen W, Yagnik G, Mascharak S, Sidorov M, Wagner JR, Shrivastav S, Kohanbash G, Okada H, Aghi MK.
Oncogene. 2017 Jun 29. 36(26):3749-3759. doi: 10.1038/onc.2017.1. PMID: 28218903.
β1 integrin targeting potentiates antiangiogenic therapy and inhibits the growth of bevacizumab-resistant glioblastoma
Carbonell WS, DeLay M, Jahangiri A, Park CC, Aghi MK.
Cancer Research. 2013 May 15; 73(10):3145-54. doi: 10.1158/0008-5472.CAN-13-0011. PMID: 23644530.
Gene expression profile identifies tyrosine kinase c-Met as a targetable mediator of antiangiogenic therapy resistance
Jahangiri A, Carbonell WS, De Lay M, Hu Y-L, Lu K, Paquette J, Tokuyasu TA, Tsao S, Chaumeil MM, Ronen SM, Bergers G, Aghi MK.
Clinical Cancer Research. 2013 Apr 1; 19(7):1773-83. doi:10.1158/1078-0432.CCR-12-1281. PMID: 23307858.
Microarray analysis verifies two distinct phenotypes of glioblastomas resistant to antiangiogenic therapy
Delay M, Jahangiri A, Carbonell WS, Hu YL, Tsao S, Tom MW, Paquette J, Tokuyasu TA, Aghi MK.
Clinical Cancer Research. 2012 May 15; 18(10):2930-42. doi:10.1158/1078-0432.CCR-11-2390. PMID: 22472177.
Tumor cell autophagy as an adaptive response mediating resistance to treatments such as antiangiogenic therapy
Hu YL, Jahangiri A, Delay M, Aghi MK.
Cancer Research. 2012 Sep 1; 72(17):4294-9. doi: 10.1158/0008-5472.CAN-12-1076.